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Abstract #3531

Analysis of QSM and PDFF Maps in an Animal Model of Duchenne Muscular Dystrophy

Jacob Degitz1, Edith Touchet-Valle2, Donald Bowen1, Joey Busher1, Steven M Wright2, Peter Nghiem3, and Mary P McDougall1
1Biomedical Engineering, Texas A&M University, College Station, TX, United States, 2Electrical Engineering, Texas A&M University, College Station, TX, United States, 3Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States

Synopsis

Keywords: Susceptibility/QSM, Muscle, Large Animals, Muscular Dystrophy, Analysis/Processing

Motivation: Quantitative susceptibility mapping (QSM) could serve as a useful tool in evaluating Duchenne muscular dystrophy due to the unique susceptibility characteristics of muscle and dystrophic calcifications in animal models.

Goal(s): The goal of this work is to identify magnetic susceptibility biomarkers in the golden retriever muscular dystrophy model.

Approach: 2D GRE images of animal subjects were acquired, which were used to obtain proton density fat fraction (PDFF) and susceptibility maps.

Results: Calcifications were not identified in muscle. A significant susceptibility difference was measured between muscles (regardless of PDFF) and fat. Significant susceptibility differences were not measured between high and low PDFF muscles.

Impact: QSM has the potential to identify novel biomarkers in musculoskeletal disorders, and further protocol development is needed to ensure reliable results for in vivo studies.

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