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Abstract #3540

Fingerprint of in vivo histology MRI in drug-resistant temporal lobe epilepsy patients

Siawoosh Mohammadi1,2,3,4, Noémie Camille Rachel Sura5, Laurin Mordhorst1, Nina Lüthi1, Jan-Malte Oeschger1, Björn Fricke1, Ora Ohana5, Martina F. Callaghan6, Nikolaus Weiskopf3,6,7, Ileana Jelescu8, Filip Szczepankiewicz89, Arthur Chakwizira9, David Carmichael10, Jose P. Marques11, Markus Nilsson12, Thomas Sauvigny5, and Francisco J. Fritz1,2
1Department of Neuroradiology, Lübeck University, Lübeck, Germany, 2Department of System Neuroscience, Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Max Planck Research Group MR Physics,, Max Planck Institute for Human Development, Berlin, Germany, 5Department of Neurosurgery, Hamburg, Germany, 6Functional Imaging Laboratory, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 7Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth System Sciences, Leipzig University, Leipzig, Germany, 8Department of Radiology, , Lausanne University Hospital (CHUV), Lausanne, Switzerland, 9Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden, 10Imaging Physics & Engineering Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, London, United Kingdom, 11Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands, 12Lund University, Lund, Sweden

Synopsis

Keywords: Multi-Contrast, Microstructure, In-vivo Histology using MRI; hMRI Fingerprint; drug-resistant temporal lobe epilepsy;

Motivation: In drug-resistant temporal-lobe epilepsy (dTLE) clear identification of lesions in standard clinical MRI is advantageous for successful surgical planning, but non-invasive access to microstructure via in-vivo histology MRI (hMRI) remains unassessed.

Goal(s): To test whether the hMRI fingerprint reveals information beyond standard clinical MRI in neurosurgery target regions.

Approach: In two patients (one MR-atrophic, the other MR-hyperintense), we used interhemispheric differences as a proxy for asymmetric dTLE-relevant abnormalities and assess their profile across hMRI metrics. We tested consistency of hMRI fingerprints across patients.

Results: hMRI fingerprint shows a significant correlation across patients in the amygdala, with a stronger profile in the MR-hyperintense patient.

Impact: Novel MRI contrasts can improve our understanding of lesion microstructure in epilepsy. This study shows consistent fingerprints of hMRI metrics across two patients with different MR-clinical findings, indicating that hMRI might complement clinical MRI by revealing information about tissue microstructure.

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Abstract

Keywords