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Abstract #3547

Evaluating 3D-EPI and FLASH-based multi-parameter mapping in temporal lobe epilepsy: a traveling head study

Nina Lüthi1,2, Francisco J. Fritz1,2,3, Laurin Mordhorst1,2, Luke J. Edwards3, Kerrin J. Pine3, Nikolaus Weiskopf3, Difei Wang4, Tony Stöcker4,5, Rüdiger Stirnberg4, Martina F. Callaghan6, Philippa Bridgen7,8, Zihan Ning7, Shaihan Malik7, David Leitão7, David W. Carmichael7, and Siawoosh Mohammadi1,2,3
1Institute for Neuroradiology, University of Lübeck, Lübeck, Germany, 2Department of Systems Neurosciences, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 5Department of Physics and Astronomy, University of Bonn, Bonn, Germany, 6Functional Imaging Laboratory, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 7Imaging Physics & Engineering Research Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 8Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Multi-Contrast, Multi-Contrast, Reproducibility

Motivation: Drug-resistant temporal lobe epilepsy (TLE) can benefit from quantitative magnetic resonance imaging (MRI) such as multi-parameter mapping (MPM) for improved identification of epileptogenic regions. Traditional MPM protocols are often too time-consuming for clinical use.

Goal(s): This study evaluates the reproducibility of time-efficient 3D-EPI MPM sequences against traditional FLASH to assess their clinical applicability in TLE.

Approach: Four subjects were scanned across five 3T MRI sites with both 3D-EPI and FLASH. Qualitative and quantitative analysis was conducted for comparison.

Results: 3D-EPI MPM demonstrated similar reproducibility to FLASH, suggesting it could be a faster alternative for MPM imaging in clinical TLE.

Impact: We demonstrate the potential of using 3D-EPI for efficient MPM acquisition for characterising regional differences in epileptogenic regions. However, it´s unclear whether our results translate to detecting subtle abnormalities in clinical application due to, e.g. reduced spatial resolution of 3D-EPI.

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Abstract

Keywords