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Abstract #3558

Altered static and dynamic functional connectivity of visual-oculomotor pathway in childhood basic-type intermittent exotropia

Mengdi zhou1, Qinglei Shi2, Huixin Li3, Mengqi Su4, Haoran Zhang5, Jie Hong3, Xiwen Wang6, Xianchang Zhang7, Xiang Wan8, Jing Fu3, and Zhaohui Liu6
1Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Bei jing, China, 2Chinese University of Hong Kong (Shenzhen) School of Medicine, Shenzhen Research Institute of Big Data, People's Republic of China, Shenzhen, China, 3Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China, 4Chinese University of Hong Kong (Shenzhen) School of Science and Engineering, People's Republic of China, Shenzhen, China, 5Chinese University of Hong Kong (Shenzhen) School of Data Science, People's Republic of China, shenzhen, China, 6Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China, 7MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China, 8Shenzhen Research Institute of Big Data, People's Republic of China, Shenzhen, China

Synopsis

Keywords: Functional Connectivity, fMRI (resting state)

Motivation: To explore the functional abnormalities of the visual-oculomotor pathway in basic-type intermittent exotropia (IXT) children.

Goal(s): To uncover the neural basis of basic-type IXT by investigating the functional connectivity (FC) alterations.

Approach: We used sliding-window and the k-means to investigate static FC (sFC) and dynamic FC (dFC) alterations.

Results: Decreased sFC between right BA19 and left BA8, and between left BA8 and right BA8, increased dFC between left BA19 and right BA18, and between left BA19 and right BA8 were found in IXT children. Moreover, the mean dwell time and fraction time in state 1 were positively associated with the duration of disease.

Impact: Children with basic-type IXT exhibited aberrant sFC and dFC in bilateral higher visual cortex-oculomotor cortex pathways. These findings provide a new perspective to understand the neuropathological mechanisms of visual perception and oculomotor impairments associated with basic-type IXT.

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Keywords