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Abstract #3561

Age-related changes in intrinsic connectivity in the hippocampus

Qihui Wang1,2, Yifei Zhang3, Xiuqin Jia1,2, and Qi Yang1,2
1Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China, 2Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China, 3GE Healthcare, Beijing, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, aging

Motivation: Age-related cognitive decline remains poorly understood, particularly regarding hippocampal subregion networks.

Goal(s): To investigate differences in hippocampal subregion networks between young and older adults.

Approach: MRI and neuropsychological assessments were used to evaluate hippocampal connectivity in 298 participants.

Results: Older adults showed reduced overall functional connectivity in the hippocampus, but a compensatory increase specifically in the CA1 subregion, suggesting mechanisms that help maintain cognitive function despite hippocampal atrophy.

Impact: This study provides important insights into the brain mechanisms underlying age-related cognitive decline, specifically highlighting MRI-based changes in hippocampal intrinsic connectivity. These findings also suggest potential targets for hippocampus-targeted interventions to mitigate cognitive decline.

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