Keywords: Functional Connectivity, Brain Connectivity, aging
Motivation: Age-related cognitive decline remains poorly understood, particularly regarding hippocampal subregion networks.
Goal(s): To investigate differences in hippocampal subregion networks between young and older adults.
Approach: MRI and neuropsychological assessments were used to evaluate hippocampal connectivity in 298 participants.
Results: Older adults showed reduced overall functional connectivity in the hippocampus, but a compensatory increase specifically in the CA1 subregion, suggesting mechanisms that help maintain cognitive function despite hippocampal atrophy.
Impact: This study provides important insights into the brain mechanisms underlying age-related cognitive decline, specifically highlighting MRI-based changes in hippocampal intrinsic connectivity. These findings also suggest potential targets for hippocampus-targeted interventions to mitigate cognitive decline.
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