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Abstract #3567

Directed fMRI connectivity mapping reveals a flexible functional hierarchy in the mouse brain

Silvia Gini1,2, Loren Kocillari3, Marco Celotto3, Ludovico Coletta4, Stefano Panzeri3, and Alessandro Gozzi1
1Functional Neuroimaging Laboratory, CNCS, Istituto Italiano di Tecnologia, Rovereto, Italy, 2Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy, 3Institute for Neural Information Processing, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany, 4Fondazione Bruno Kessler, Trento, Italy

Synopsis

Keywords: Functional Connectivity, Neuro, Directed Functional Connectivity

Motivation: fMRI connectivity is widely used to probe brain functional organization. However, measures of fMRI connectivity are typically undirected and insensitive to the information transfer between brain regions.

Goal(s): We hypothesized that directed fMRI connectivity mapping would reveal a novel dimension in the functional organization of the mammalian brain: do brain regions exchange information equally, or are there regional sources or sinks of information?

Approach: We validated the use of directed connectivity mapping via transfer entropy to characterize directed connectivity in the resting mouse brain.

Results: We reveal a robust, intrinsic source-to-sink organization in the mouse brain that flexibly reconfigures depending on brain state.

Impact: Our study shows that resting state fMRI can be reliably used to probe directed information transfer between brain regions.

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Keywords