Keywords: Functional Connectivity, fMRI (resting state), Preclinical, fiber photometry, hemodymic, awake mouse, SORDINO
Motivation: Robust correlations between bilateral striatal connectivity have been broadly reported; however, direct anatomical projections across hemispheres in this region are absent. The circuit mechanism remains unknown.
Goal(s): We propose to elucidate the circuit origins of interhemispheric striatal resting-state fMRI connectivity using simultaneous fMRI and spectrally resolved triple-sensor fiber photometry.
Approach: We measured neuronal calcium, dopamine, and glutamate dynamics in the striatum during fMRI.
Approach: We measured neuronal calcium, dopamine, and glutamate dynamics in the striatum during fMRI.
Results: Dopamine shows the most robust correlation between striatal regions.
Impact: This work provides evidence-based interpretation of the rs-fMRI connectivity between striatum of the two hemispheres, which is crucial for motor control, cognition, motivation behavior, and several neurological disorders.
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