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Abstract #3570

Simultaneous fMRI and triple-sensor fiber photometry reveal the neurochemical correlates of bilateral striatal connectivity

Wei-Ting Zhang1, Sheng Song1, Li-Ming Hsu2, Randy Nonneman1, Winne Tzu-Wen Wang1, Mabelle Sardinas1, Harry Tzu-Hao Chao1, and Yen-Yu Ian Shih1
1Center for Animal MRI, BRIC/Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Center for Animal MRI, BRIC/Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Functional Connectivity, fMRI (resting state), Preclinical, fiber photometry, hemodymic, awake mouse, SORDINO

Motivation: Robust correlations between bilateral striatal connectivity have been broadly reported; however, direct anatomical projections across hemispheres in this region are absent. The circuit mechanism remains unknown.

Goal(s): We propose to elucidate the circuit origins of interhemispheric striatal resting-state fMRI connectivity using simultaneous fMRI and spectrally resolved triple-sensor fiber photometry.
Approach: We measured neuronal calcium, dopamine, and glutamate dynamics in the striatum during fMRI.

Approach: We measured neuronal calcium, dopamine, and glutamate dynamics in the striatum during fMRI.

Results: Dopamine shows the most robust correlation between striatal regions.

Impact: This work provides evidence-based interpretation of the rs-fMRI connectivity between striatum of the two hemispheres, which is crucial for motor control, cognition, motivation behavior, and several neurological disorders.

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Keywords