Abstract #3600

Increased Regional Brain Temperatures in Obstructive Sleep Apnea Adults

Bhaswati Roy¹, Luke Ehlert¹, Ravi Aysola², Daniel W. Kang², Sulaiman A. Sheriff³, Andrew A. Maudsley³, and Rajesh Kumar^1,4,5,6

¹Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, ⁴Radiology, University of California Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States, ⁶Bioengineering, University of California Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Neuroinflammation, Brain, 3D echo planar spectroscopic imaging (EPSI), Obstructive sleep apnea (OSA), brain temperature

Motivation: OSA adults show impaired functions, likely resulting from brain changes in sites that mediate such functions, but the pathological mechanisms contributing to brain tissue changes are unclear. Intermittent hypoxia(IH) induces oxidative stress, leading to neuroinflammation and activation of immune and glial cells, which may contribute to increased regional brain temperature, leading to localized brain tissue changes.

Goal(s): Our goal was to examine regional brain temperatures in OSA and control adults.

Approach: Non-invasive 3D-EPSI data were used to generate temperature maps which were compared between groups.

Results: We observed increased brain temperature in OSA adults, likely due to IH-induced oxidative stress and mitochondrial dysfunction.

Impact: We observed increased regional brain temperature in OSA adults, which have never been studied before, and have implication in identifying interventions and improving the morbidity, mortality, and quality of life in the condition.

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