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Abstract #3601

Alterations in MRI indices of Glymphatic System in Systemic Lupus Erythematosus: A Focus on Networks of Perivascular Spaces

Jingyi Wang1, Kunyu Zhuang2, Jiaying Mo1, Hai Lin3, and Xiangliang Tan1
1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2The First Clinical Medical School, Southern Medical University, Guangzhou, China, 3United Imaging Research, United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Neuroinflammation, Nervous system, Glymphatic system

Motivation: The mechanism of neurological changes in SLE patients remains unknown, and MRI is a noninvasive method used to estimate the Glymphatic System function.

Goal(s): To investigate whether the function of Glymphatic System is impaired in SLE patients.

Approach: We employed three noninvasive MRI indices: perivascular space (PVS), extracellular free water (FW), and diffusion tensor imaging analysis along PVS (DTI-ALPS) to assess the Glymphatic System function of SLE patients.

Results: Compared to HCs, patients with SLE had significantly higher PVSVF-WM and FW-WM values, as well as lower ALPS-index. Furthermore, we found significant correlations among three MRI indices of the Glymphatic System across all participants.

Impact: Our study revealed impairments in Glymphatic System of SLE patients, providing a noninvasive MRI biomarkers for comprehensively quantifying Glymphatic activity in SLE patients. Furthermore, the correlations among the components of Glymphatic System may explain the relationships among its structural compartments.

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