Keywords: Neuroinflammation, Brain, metabolic syndrome, choroid plexus, magnetic resonance imaging, high-density lipoprotein, hypertension, cognitive function
Motivation: To explore changes in the choroid plexus (CP) volume in metabolic syndrome (Mets) and how these changes correlate with cognitive performance.
Goal(s): This study aimed to investigate the specific components of Mets that exert the greatest influence on CP volume changes and whether they affect cognition performance.
Approach: Mets patients and healthy controls were compared using TIWI and diffusion tensor imaging, and with multiple cognitive tests. Changes in the CP volume were recorded.
Results: Our findings showed that the CP volume mediates the relationship between high-density lipoprotein and multiple cognitive tests.
Impact: The elevated choroid plexus volume in Mets may be a neuroimaging indicator associated with cognitive impairment. Mets risk factors significantly affect the choroid plexus volume, and these volume changes are negatively correlated with cognitive performance.
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