Abstract #3631

Multi-Modality Quantitative Fat Phantom for MRI and CT Measurements of Steatotic Liver Disease

David R Rutkowski¹, Jeff Kammerman¹, José Guerrero-González¹, Robert Moskwa¹, Ke Li², Timothy P Szczykutowicz², Scott B Reeder^1,2,3,4,5,6, Diego Hernando^1,2,3, and Jean H Brittain¹

¹Calimetrix, LLC, Madison, WI, United States, ²Medical Physics, University of Wisconsin, Madison, WI, United States, ³Radiology, University of Wisconsin, Madison, WI, United States, ⁴Biomedical Enginering, University of Wisconsin, Madison, WI, United States, ⁵Medicine, University of Wisconsin, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Phantoms, Phantoms, CT

Motivation: A quantitative multi-modality fat phantom would facilitate quality assurance of liver fat quantification with MRI and CT.

Goal(s): Develop a quantitative MRI-CT fat phantom that mimics MRI and CT properties of liver, including CT energy dependence.

Approach: Vials were fabricated and placed into a newly designed pill-shaped housing and assessed on MRI and CT systems.

Results: MRI and CT measurements were correlated by CT#[HU] = -2.57*PDFF+0.04*kV+0.0048*PDFF*kV+66.19, where PDFF is measured in % and kV is CT tube potential. The maximum CT number difference between 80 kV and 140 kV CT acquisitions was 14 HU.

Impact: A quantitative multi-modality fat phantom was developed for quality assurance of MRI and CT fat quantification. The phantom mimics MRI proton-density fat fraction (PDFF) from 0-40% PDFF and the liver fat-to-CT# relationship, including the CT response across multiple kV levels.

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