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Abstract #3636

3D Boundaryless Slab Phantoms

Izabel Wu1, Karthik Gopalan1, Abigail Falk1, Jolene Huey1, Ana Arias1, Chunlei Liu1, and Michael Lustig1
1Electrical Engineering & Computer Sciences, UC Berkeley, Berkeley, CA, United States

Synopsis

Keywords: Phantoms, Phantoms

Motivation: Modern MRI phantoms rely on physical boundaries to prevent ionic diffusion of T1/T2 modifiers across compartments. Boundaryless phantoms would more accurately mimic the heterogeneity of human anatomy.

Goal(s): Produce a stable, anatomically accurate, quantitative, and boundaryless brain phantom.

Approach: Segment Brainweb1 data into white and gray matter tissues, 3D print positive molds, cast negative silicone molds, then fill the molds with doped UV-curable hydrogels.

Results: We developed a process to create a boundaryless phantom of white and gray matter with stable T2 contrast using iron oxide nanoparticles.

Impact: To address the need for quantitative phantoms with complex, anatomically accurate geometry, we developed stackable boundaryless slab phantoms by casting UV-curable hydrogels doped with a stable T2 contrast modifier. The phantoms represent roughly 40% of the top of the brain.

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