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Abstract #3637

Liquid Like Solids: A promising, novel multicompartment diffusion MRI phantom material

Courtney J Comrie1, Malcolm Barrios1, Isabella Aguilera Cuenca2, Alexander J McGhee1, Jindi Sun1, Shang Song1,3,4, and Elizabeth B Hutchinson1
1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Optical Sciences, University of Arizona, Tucson, AZ, United States, 3Neuroscience, University of Arizona, Tucson, AZ, United States, 4Materials Science and Engineering, University of Arizona, Tucson, AZ, United States

Synopsis

Keywords: Phantoms, DWI/DTI/DKI, multicompartment phantom, diffusion phantom

Motivation: Traditional single-compartment phantoms lack control over pore size, are more indicative of water restriction, and have limited biological relevance.

Goal(s): Evaluate liquid-like solids (LLS) as a potential dual-compartment phantom material for dMRI.

Approach: LLS phantoms, prepared with different gel concentrations, were imaged with b=0-2500s/mm2 and the signal curves were compared with free water and silica gel, a restricted phantom material. Additionally, several frameworks were evaluated for multi-compartment dependence.

Results: LLS phantoms show double-exponential DWI signal decay and gel concentration correspondence with dMRI-estimated volume fraction, with Gaussian and non-Gaussian frameworks showing measurable bias, supporting this material's utility in refining multicompartment models.

Impact: Developing biologically relevant multicompartment materials as phantoms can support the advancement of dual tensor and compartment imaging models, allowing innovation and development in more sophisticated diffusion imaging techniques.

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