Abstract #3638

Multi-center and multi-vendor phantom study on ADC accuracy, repeatability and reproducibility across 1.5T and 3T MRI scanners

Siria Pasini¹, Steffen Ringgaard², Leyre Garcia-Ruiz³, Anika Strittmatter^4,5, Giulia Villa⁶, Anish Raj^4,5, Rebeca Echeverria-Chasco³, Michela Bozzetto⁶, Paolo Brambilla⁷, Malene Aastrup², Esben Søvsø Szoc Hansen², Luisa Pierotti⁸, Matteo Renzulli⁸, Susan Francis⁹, Frank Zoellner^4,5, Christoffer Laustsen², Maria Fernandez-Seara³, and Anna Caroli¹

¹Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, ²The MR Research Centre, Aarhus University, Aarhus, Denmark, ³Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain, ⁴Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁵Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁶Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, ⁷ASST Papa Giovanni XXIII, Bergamo, Italy, ⁸IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy, ⁹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Phantoms, Diffusion Acquisition

Motivation: Apparent diffusion coefficient (ADC) is a promising imaging biomarker for tissue characterization, particularly in renal applications. However, diffusion metrics variation across scanners poses challenges for multi-center studies.

Goal(s): Our aim was to demonstrate the feasibility of QIBA validation process for ADC measurements in abdominal setups at 1.5T and 3T across multiple sites and vendors.

Approach: In six sites, ADC values were measured on the QIBA/NIST diffusion phantom and compared to reference values, adjusting for temperature.

Results: Excellent accuracy, repeatability and reproducibility were found, especially in the renal range. Despite some differences across field strengths and vendors the overall inter-scanner agreement was excellent.

Impact: Implementing the QIBA validation process, using standardized protocols across sites and vendors, for diffusion measurements is feasibile in abdominal setups at both 1.5T and 3T. This is a crucial step to enhance reliability in multi-center renal MRI studies.

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