Abstract #3640

A standardized MRI Phantom for Quantitative Functional Imaging of the Lung Parenchyma in Health and Disease

Thomas Meersmann^1,2,3, Max Filkins^1,4, Arthur Harrison^1,2, Guilhem J Collier^5,6, Graham Norquay^5,6, Jim M Wild^5,6, Chengbo Wang³, Sean P Rigby⁴, and Galina E Pavlovskaya^1,2

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ³Centre for Life Science and Health Care, University of Nottingham, Ningbo, China, ⁴Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, United Kingdom, ⁵POLARIS, University of Sheffield, Sheffield, United Kingdom, ⁶POLARIS, Department of Infection Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Phantoms, Phantoms, Hyperpolarised MR (Gas), Pulmonary MRI, Dissolved phase xenon-129 phantom

Motivation: Pulmonary MRI with dissolved phase hyperpolarized xenon-129 (hp¹²⁹Xe) holds significant diagnostic potential for the clinical assessment of gas exchange. However, a universal phantom standard is currently missing to facilitate better quantitative data comparison between various sites.

Goal(s): Develop a phantom standard that emulates hp¹²⁹Xe signals in human lungs

Approach: Identify and quantitatively describe suitable materials that dissolve xenon, mimic gas uptake, and reproduce hp¹²⁹Xe chemical shift in lungs. Build a phantom and obtain signal ratios with clinical MRI protocols.

Results: Materials were identified that reproduced spectral signatures and signal ratios comparable to those in human lungs in health and disease.

Impact: The current phantom enables cost-effective training, easy setup, and rapid testing of experimental protocols without regulatory approval and governance. The introduced concept shows a pathway for developing a quantitative universal phantom standard for dissolved phase hp¹²⁹Xe MRI

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