Keywords: Biology, Models, Methods, Functional Connectivity, fMRI (resting-state); biology, models, methods; neuroscience; fMRI analysis
Motivation: Our comprehension of the role of the zona incerta (ZI) in brain-wide functional connectivity remains limited despite recent knowledge of incertal projections and functions.
Goal(s): We aim to examine the role of inhibitory ZI in the regulation of functional connectivity in brain-wide networks.
Approach: We employed optogenetic fMRI to directly initiate neural activity at ZI and monitor brain-wide functional connectivity before, during, and after stimulations.
Results: ZI inhibitory activity reshaped brain-wide functional connectivity by driving the emergence of cortical-cortical cooperative and cortical-subcortical antagonistic network motifs.
Impact: We posit that the findings from this study will provide critical insights into where and how ZI neural activities are distributed throughout the brain, and their contributions to brain functional connectivity.
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