Abstract #3644

Dissecting the strain and sex specific connectome signatures of unanesthetized C57BL/6J and DBA/2J mice using MRI

Tanzil Mahmud Arefin¹, Hayreddin Said Ünsal², Thomas Neuberger², Nanyin Zhang², and Helen Marie Kamens³

¹Department of Neuroscience, Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center, Rochester, NY, United States, ²Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States, ³Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, United States

Synopsis

Keywords: Small Animals, Brain Connectivity, C57BL/6J, DBA/2J, awake rsfMRI, diffusion MRI

Motivation: Mouse models have become an essential tool for understanding behavior and disease states in neuroscience research. However, genetic and sex-specific neurochemical and neuroanatomical features of mice raise questions of the impact of these known factors.

Goal(s): To bridge this gap, we targeted C57BL/6J and DBA/2J, two of the most widely used inbred mouse strains, and investigated strain and sex-specific features of the brain connectome using MRI.

Approach: We combined rsfMRI and diffusion-MRI to probe the mouse brain non-invasively.

Results: We found that the sensori-motor, limbic, and salience networks show significant differences in both functional and structural domains between C57BL/6J and DBA/2J mice.

Impact: Understanding strain and sex-dependent signatures of the brain connectome is extremely important to consider when determining neural mechanisms that explain complex behavioral and disease states.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.