Keywords: Biomarkers, Preclinical, Oxygenation, Oxygen extraction fraction, quantitative susceptibility mapping, quantitative blood oxygen level dependent imaging, QSM, qBOLD, QSM+qBOLD, QQ
Motivation: Oxygen extraction fraction (OEF) is a direct biomarker for tissue viability. A novel OEF mapping technique, QQ, has shown potential by detecting disease-related OEF abnormalities. Although QQ-based OEF is promising for oxygen metabolism-related preclinical research, it has not yet been tested in animal brains.
Goal(s): To apply QQ to mouse brains for the first time, examining its sensitivity to physiological OEF changes.
Approach: Five mice underwent OEF processing at varying isoflurane levels to investigate the relationship between OEF and isoflurane levels.
Results: QQ provided uniform OEF map in mice, with OEF decreasing as isoflurane increased, demonstrating QQ’s sensitivity to physiological change.
Impact: These findings validate QQ’s application in mouse models, enabling detailed investigations into cerebral oxygen metabolism under various physiological and pathological conditions. Preclinical QQ-based OEF will therefore be highly beneficial for understanding disease mechanisms and treatment effects in neurologic disorders.
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