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Abstract #3653

Multi-parametric MRI study of stroke in Model Aged Hypertensive Rats

Asamoah Bosomtwi1,2, Abdulkarim Alshammari3,4, Bindu Pillai3, Roxan Ara1, Pradip Kamat5, and Susan C Fagan3
1Georgia Cancer Center, Augusta University, Augusta, GA, United States, 2Biochemistry and Molecular Biology, Augusta University, Augusta, GA, United States, 3University of Georgia, Augusta, GA, United States, 4Norther Border University, Rafha, Saudi Arabia, 5Neurology, Augusta University, Augusta, GA, United States

Synopsis

Keywords: Small Animals, Aging

Motivation: The synergistic effects of hypertension and aging on brain morphology is described and the evolution patterns of cerebral atrophy from spatial and temporal perspectives using Rat stroke model.

Goal(s): Using non-invasive MRI techniques, we have investigated changes in the brain of 18-month-old spontaneously hypertensive (SHR) rats following a 30-minute transient middle cerebral artery occlusion (tMCAO) or SHAM for 8 weeks.

Approach: Using multi-parametric MRI data to access the treatment efficacy

Results: Our results demonstrate that treatment of stroke with Angiotensin type 2 receptor (AT2R) agonist reduced lesion volume compare to non-treated group.

Impact: The C21-treatement improve outcome.

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