Abstract #3654

Common coordinate framework of developmental macaque brain from birth to early childhood based on ultra-high-resolution diffusion MRI

Ziqin Zhang^1,2, Tianjia Zhu^1,2, Jianlin Guo^1,3, Minhui Ouyang^1,4, Andre Sousa⁵, Jon Levine⁵, Arnold Kriegstein⁶, and Hao Huang^1,4

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Bioenginnering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Radiology, Beijing Children's Hospital, Beijing, China, ⁴Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Neurology, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Normal Development, Normal development, nonhuman primates, ultra-high resolution, diffusion MRI, common coordinate framework

Motivation: Macaque brain structures undergo significant changes from birth through adulthood. However, there are no age-specific macaque brain common coordinate frameworks (CCFs) serving as neuroanatomical references for mapping genetic, cellular, and molecular information.

Goal(s): To establish ultra-high-resolution CCFs for macaque brain at birth and early childhood (10-months).

Approach: We acquired ultra-high resolution diffusion MRI (dMRI) of neonate and early-childhood macaque brains and delineated whole-brain neuroanatomical structures. We also investigated macaque white matter tract maturation through dMRI-based tractography.

Results: The established neonate and early childhood macaque brain CCFs feature 0.2mm isotropic ultra-high diffusion imaging resolution, comprehensive gray and white matter labels, and a coordinate framework.

Impact: These first age-specific developmental macaque brain CCFs, featuring 0.2mm isotropic ultra-high-resolution diffusion imaging, serve as neuroanatomical references. They facilitate the mapping of genetic, cellular, and molecular data and offer image templates, establishing foundations for discoveries in brain development and evolution.

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