Abstract #3655

Vascular and metabolic responses to elevated circulating PDGF-BB in mice: A multiparametric MRI study

Xiuli Yang¹, Jiekang Wang^2,3, Yuguo Li^1,4, Mei Wan³, and Zhiliang Wei^1,4

¹Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Biomarkers, Small animals

Motivation: Elevated circulating PDGF-BB has been implicated in various aging-related processes. However, there is a lack of neurofunctional proof to support the underlying relationship.

Goal(s): Here, we aim to investigate the vascular and metabolic responses to elevated circulating PDGF-BB in mice.

Approach: Non-contrast-agent multiparametric MRI methods were applied to examine the potential alterations in cerebral blood flow (CBF), oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen (CMRO2), and brain microstructures.

Results: We found that elevated circulating PDGF-BB was associated with impaired blood supply and elevated brain metabolism, suggesting that excessive circulating PGDF-BB is a pro-aging factor.

Impact: Excessive circulating PDGF-BB is associated with impaired blood supply and hypermetabolism in mice, which aligns with the major pathophysiological changes in human aging. It provides a functional proof that excessive PDGF-BB is a pro-aging factor and a potential therapeutic target.

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