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Abstract #3656

Investigating Abnormal Glymphatic Function and Perivascular Space in Alzheimer’s Disease Using Dynamic Contrast-Enhanced MRI and DTI-ALPS

Yao-Wen Liang1, Ching-Wen Chang2,3, Ssu-Ju Li4, Tsai-Yu Cho1, Ting-Chieh Chen1, Cheng-Ru Yang1, Yu-Chun Lo5, and You-Yin Chen1,5
1Biomedical engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, 3Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan, 4Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, 5PhD Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Synopsis

Keywords: Small Animals, Alzheimer's Disease

Motivation: The correlation between glymphatic function and perivascular space (PVS) remains unclear in Alzheimer’s disease (AD).

Goal(s): To investigate the relationship between glymphatic function and PVS in AD animal model.

Approach: Dynamic contrast-enhanced MRI (DCE-MRI) and diffusion tensor imaging (DTI) were used to investigate the difference of perfusion function and PVS between wild-type (WT) and AD group.

Results: Larger ratio of DTI-ALPS and weaker glymphatic function were found in AD group.

Impact: This study reveals the relationship between glymphatic function and PVS in AD animal model.

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Abstract

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