Abstract #3666

Preliminary findings from 4D-flow MRI on left heart hemodynamics in Chronic Obstructive Pulmonary Disease: The SPIROMICS Heart Failure Study

Melika Shafeghat¹, David Dushfunian¹, Michael Markl¹, Tim Houston², Oliver Wieben2², Martine R Prince³, Wei Shen³, David Bluemke², Kristina L Buschur³, Michael C Backman³, Sachin R. Jambawalikar³, Bharath Ambale Venkatesh⁴, Joao Lima⁴, Prachi Agarwal⁵, Meilan Han⁵, Steven Lloyd⁶, J. Paul Finn⁷, Igor Barjaktarevic⁷, Christopher B. Cooper⁷, Jing Liu⁸, Joyce Schroeder⁹, Robert Pain⁹, Dalane W Kitzman¹⁰, Jens Vogel-Claussen¹¹, R. Graham Barr³, and James Carr¹

¹Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ²University of Wisconsin-Madison, Madison, WI, United States, ³Columbia University Medical Center, New York, NY, United States, ⁴Johns Hopkins University, Baltimore, MD, United States, ⁵University of Michigan School of Medicine, Ann Arbor, MI, United States, ⁶University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States, ⁷University of California, Los Angeles, Los Angeles, CA, United States, ⁸University of California San Francisco, San Francisco, CA, United States, ⁹University of Utah School of Medicine, Salt Lake City, UT, United States, ¹⁰Wake Forest University, Winston-Salem, NC, United States, ¹¹Hannover University, Hannover University, Germany

Synopsis

Keywords: Flow, Cardiovascular, Chronic Obstructive Pulmonary Disease

Motivation: Chronic obstructive pulmonary disease (COPD) is associated with heart failure.

Goal(s): To investigate hemodynamic changes in the left-sided heart chambers using 4D-flow MRI and evaluate their correlation with COPD severity.

Approach: We analyzed fifty 4D-flow MRI cases from the SPIROMICS HF study.

Results: A significant negative correlation was found between the energy loss to kinetic energy ratio and forced vital capacity in the left ventricle (r = -0.37, p =0.014). Maximum velocity in the aorta also negatively correlated with residual lung volume (r = -0.31, p = 0.035), indicating impaired left heart hemodynamics in COPD patients.

Impact: Our findings emphasized using 4D-flow MRI as a noninvasive method for evaluating heart function in COPD patients. This opens new research into therapies targeting heart-lung interactions, improving outcomes that were previously unattainable.

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