Abstract #3696

Whole-cerebrum isotropic 1 mm Arterial Spin Labeling Perfusion at 7T with Improved Temporal Resolution

Chenyang Zhao¹, Fanhua Guo¹, Zidong Yang¹, Qinyang Shou¹, Xingfeng Shao¹, Alexander Beckett², Erica Walker², Samantha Ma³, David A Feinberg², and Danny JJ Wang¹

¹Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Erwin Hahn 7T MRI Laboratory, Henry H. Wheeler Brain Imaging Center, Helen Wills Neuroscience Institute, Department of Neuroscience, University of California, Berkeley, Berkeley, CA, United States, ³Siemens Medical Solutions USA, Los Angeles, CA, United States

Synopsis

Keywords: Arterial Spin Labelling, Perfusion

Motivation: Leveraging the benefits of 7T MRI, high spatial and temporal resolution Arterial Spin Labeling perfusion imaging has the potential to provide fine-grained structural and functional information of the brain.

Goal(s): We aim to improve temporal resolution for perfusion imaging while maintaining iso-1mm resolution and whole-cerebrum coverage.

Approach: We developed a novel 3D TFL-pCASL sequence combined with Golden-angle Stack-of-Spirals, dynamic compressed sensing, and high-performance gradient system on NextGen 7T.

Results: The method enabled accurate measurement of laminar CBF profile, reduced motion artifact, and captured functional activation in motor and visual cortices with a temporal resolution as high as 14 seconds.

Impact: This study presents high spatial and temporal resolution ASL perfusion imaging at 7T, providing motion-robust, fast, and fine-grained structural and functional information of the brain.

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