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Abstract #3714

Impact of Drowsiness on EEG-fMRI Dynamics and Physiological Responses During Eyes-Open and Short Resting State Scans

Kadir Berat YILDIRIM1, Lina Alqam1, Kubra Eren1, Elif Can1, Cem Karakuzu1, Belal Tavashi1, Alp Dincer2, and Pinar Senay Ozbay1
1Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Department of Radiology, Acibadem Hospital, Istanbul, Turkey

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), fmri, eeg, drowsiness

Motivation: Drowsiness impacts brain function and physiology, affecting the interpretation of resting-state fMRI scans. Understanding its dynamics is crucial for accurate analysis.

Goal(s): Investigate how EEG-defined drowsiness, marked by alpha-power changes, modulates brain connectivity and physiological responses(heart-rate, pulse amplitude, respiratory variability) during resting-state fMRI.

Approach: Participants were grouped based on alpha power shifts. EEG-fMRI data were correlated with heart rate, pulse amplitude, and respiratory variability.

Results: In drowsy state, HR showed stronger correlations with the ACC and visual cortex, indicating greater synchrony between brain and heart. PPG-AMP coupled more with sensory regions, and RV linked to DMN areas, with reduced connectivity in drowsy group.

Impact: This study provides new insights into the effects of drowsiness on brain-physiological interactions, which could improve the interpretation of resting-state fMRI scans in both research and clinical settings.

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Keywords