Keywords: fMRI Analysis, fMRI (task based)
Motivation: There is growing demand for fMRI tasks that probe the central autonomic network (CAN). Respiratory tasks (RTs) are promising but understudied in this role, due to confounding effects of CO2-related cerebrovascular reactivity.
Goal(s): To evaluate the utility of RTs in CAN assessment after correcting for CO2-related effects, by measuring sensitivity and reliability of fMRI signal in key CAN regions.
Approach: We collected fMRI data from 72 adults while they performed an RT. After respiratory volume-based corrections, we assessed CAN peak response, intraclass correlation, and effect of physiological processing model.
Results: The RT evoked significant, reliable activation in CAN regions.
Impact: This study assessed the viability of RTs in measuring autonomic function and CAN-related activity. This included assessments of task sensitivity and reliability, which support the use of this paradigm to evaluate autonomic function in healthy and clinical cohorts.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords