Abstract #3719

Functional MRI with UTE to investigate stimulus-driven CSF flow

Sara Ponticorvo¹, Ekaterina Paasonen², Pavel Filip³, Douglas Rothman⁴, Juha Valjakka², Olli Gröhn², Shalom Michaeli¹, and Silvia Mangia¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ³General University Hospital, Charles University, Prague, Czech Republic, ⁴Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States

Synopsis

Keywords: fMRI Analysis, Flow

Motivation: Dynamics of CSF-flow has been shown to relate to whole-cortex BOLD signals during intense stimulation, but the relationship with blood-flow is not known.

Goal(s): Determine the correspondence of flow-mediated UTE-fMRI signals in whole-cortex and CSF.

Approach: UTE-fMRI and BOLD-EPI were performed at 7T on 12 humans. Correlations between time-courses were calculated in atlas-based regions.

Results: We detected anticorrelated task-evoked UTE signal changes in whole-cortex and CSF. On the other hand, BOLD signals in whole-cortex correlated with those in CSF, with no clear task-evoked signal changes seen in these regions during stimulation.

Impact: Since UTE-fMRI signals are mediated by flow dynamics, they enable determining the relationship between blood-flow and CSF-flow more directly than BOLD. This opportunity is critical for understanding how the brain ensures global homeostasis during the demands of regional activity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.