Meeting Banner
Abstract #3720

Mapping the Link between Resting-State fMRI and Cerebral Oxidative Metabolism

Xiaole Z Zhong1,2, Hannah Van Lankveld2,3, and J. Jean Chen1,2,3
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Rotman Research Institute, Baycrest Academy of Research and Education, Toronto, ON, Canada, 3Department of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: fMRI Analysis, fMRI (resting state)

Motivation: By understanding the link between rs-fMRI and cerebral oxidative metabolism (CMRO2), which is directly linked to neuronal activity, we can increase the interpretability of rs-fMRI metrics.

Goal(s): This study aimed to establish associations between rs-fMRI metrics and CMRO2, and to demonstrate how our novel macrovascular correction can enhance these associations.

Approach: We measured resting CMRO2 using gas-free calibrated fMRI, and used the linear mixed-effects models to investigate its associations with various rs-fMRI metrics before and after macrovascular correction.

Results: rs-fMRI metrics were more strongly associated to CMRO2 after macrovascular correction, with global functional connectivity density being mostly strongly associated.

Impact: rs-fMRI has limited clinical interpretability due to its complicated nature. We improve the interpretability of rs-fMRI by showing which metric is more closely linked to cerebral metabolism and how links can be enhanced by reducing the macrovascular bias in rs-fMRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords