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Abstract #3723

Functional neural mechanisms and underlying structural changes are associated with treatment efficacy in amblyopia

Himanshu Singh1, Himani Gupta2, Rebika Dhiman2, S. Senthil Kumaran1, and Rohit Saxena2
1Nuclear Magnetic Resonance (NMR), All India Institute of Medical Sciences,, New Delhi, India, 2Dr. Rajendra Prasad Centre of Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India

Synopsis

Keywords: Task/Intervention Based fMRI, Brain Connectivity, Amblyopia, Functional and Structural Connectivity

Motivation: Elucidating the mechanisms underlying treatment response in amblyopia patients is essential for the development of more efficacious and individualized therapeutic approaches.

Goal(s): The utilization of functional magnetic resonance imaging (fMRI) and diffusion imaging in predicting treatment response among patients with amblyopia.

Approach: We utilized diffusion and resting-state fMRI methodologies in pre- and post-treatment assessments for amblyopic patients to evaluate functional and structural changes.

Results: The efficacy of occlusion therapy was indicative of functional homogeneity in ROI connectivity analysis, and changes within the fractional anisotropy were complementary to underlying functional connectivity.

Impact: By integrating imaging parameters and identifying predictive factors for treatment response, it is possible to develop more efficacious and individualized treatment strategies for patients with amblyopia. The functional-structural correlates observed in the study suggest treatment response efficacy.

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