Abstract #3724

BOLD responses during stroop task correlates with glutamates and gamma-aminobutyric acid at resting state

Kazuya Ouchi^1,2, Masaki Fukunaga³, and Tomokazu Tsurugizawa^1,2

¹National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan, ²Faculty of Engineering, Information and Systems, University of Tsukuba, Ibaraki, Japan, ³National Institute for Physiological Sciences (NIPS), Aiti, Japan

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based)

Motivation: Relationship between local Glu/GABA concentration and cognitive function has not been fully understood.

Goal(s): We aim to clarify the relationship between local Glu/GABA concentration and local neuronal activity related to cognitive task using MR spectroscopy and functional MRI.

Approach: We scanned functional MRI and MRS in 14 healthy adults. The Stroop task was performed during fMRI, and GABA/Glu were measured at resting state.

Results: The Glu/GABA concentration in the ACG and in the SPL was correlated with BOLD response in several brain regions, which was evoked during stroop task.

Impact: This study reveals that the concentration of Glu/GABA at resting state have a impact on brain activity related to cognitive task, suggesting that these neural metabolites could be useful as biomarkers for cognitive function.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.