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Abstract #3728

Comparing Activation-Induced Changes in Cerebral Oxygen Metabolism Measured by Calibrated fMRI and [15O]O2-PET

Graham Deller1, Linshan Liu1, Lucas Narciso2,3, Justin Hicks1, Michael C Langham4, Felix Wehrli4, and Keith St. Lawrence1
1Lawson Health Research Institute, London, ON, Canada, 2Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada, 3Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based), ASL; PET/MRI; BOLD; Cerebral oxygen metabolism

Motivation: Evaluate the accuracy of calibrated functional MRI (c-fMRI) for measuring relative changes in CMRO2.

Goal(s): Compare activation-induced increases in CMRO2 measured by c-fMRI to measurements from [15O]O2-PET.

Approach: Data acquired on a PET/MRI scanner while participants performed finger tapping. Calibrated fMRI protocol involved hypercapnia. [15O]O2-PET images acquired at rest and during tapping.

Results: Good agreement in the average CMRO2 increase in the sensorimotor cortex between the two methods, although the variability for c-fMRI was considerably greater.

Impact: This study is the first direct comparison of c-fMRI to [15O]O2-PET and demonstrated the accuracy of the MRI method.

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Keywords