Keywords: Task/Intervention Based fMRI, fMRI (task based), ASL; PET/MRI; BOLD; Cerebral oxygen metabolism
Motivation: Evaluate the accuracy of calibrated functional MRI (c-fMRI) for measuring relative changes in CMRO2.
Goal(s): Compare activation-induced increases in CMRO2 measured by c-fMRI to measurements from [15O]O2-PET.
Approach: Data acquired on a PET/MRI scanner while participants performed finger tapping. Calibrated fMRI protocol involved hypercapnia. [15O]O2-PET images acquired at rest and during tapping.
Results: Good agreement in the average CMRO2 increase in the sensorimotor cortex between the two methods, although the variability for c-fMRI was considerably greater.
Impact: This study is the first direct comparison of c-fMRI to [15O]O2-PET and demonstrated the accuracy of the MRI method.
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