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Abstract #3734

Detection of Neuronal Firings in Motor Cortex of Humans under a Task of Finger-Tapping via Quantum-Sensing MRI

Yongxian Qian1, Kennedy Watson1, Xingye Chen2, Ying-Chia Lin1, Simon Henin3, Nahbila-Malikha Kumbella1, Justin Quimbo1, Yulin Ge1, Arjun Masurkar3, Anli Liu3, and Yvonne W. Lui1
1Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, 3Neurology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Aging, Nerves, Quantum sensing

Motivation: Functional MRI techniques such as DIANA have been controversial in direct detection of neuronal electrical activities (firings) due to tiny difference between task vs. resting state. Quantum-sensing (qs) MRI is an emerging non-BOLD fMRI technique that has the potential for the direct detection.

Goal(s): To explore whether qsMRI detects neuronal firings during a task of finger-tapping.

Approach: A group of healthy subjects (age 27–84 years) was studied on a 3T MRI scanner.

Results: The qsMRI was able to detect firings, with older people showing higher firing rate during tapping than resting.

Impact: This positive outcome will encourage researchers to use the qsMRI in a wide range of studies on brain functions and neurological disorders including normal aging and Alzheimer’s disease.

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