Abstract #3741

Simultaneous High-Resolution 3D Metabolic Imaging and Myelin/Axonal Water Fraction Mapping in Multiple Sclerosis Using SPICE

Yue Guan^1,2, Ruihao Liu^1,3, Yudu Li^3,4,5, Bin Bo¹, Weijun Tang⁶, Shuoyun Feng¹, Tianyang Sheng⁷, Yibo Zhao³, Wen Jin^3,8, Xiangjun Chen⁷, Zhi-Pei Liang^3,8, and Yao Li^1,2

¹National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China, ⁷Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, Shanghai, China, ⁸Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: Improved characterization of multiple sclerosis (MS) using both neurometabolite and myelin/axonal water-based biomarkers.

Goal(s): To demonstrate simultaneous high-resolution whole-brain metabolic imaging and myelin/axonal/extracellular water fraction mapping in MS.

Approach: MRSI scans without water suppression using SPICE (11.35-min scan; T2*: 2.0×1.0×1.0 mm³; MRSI: 2.0×3.0×3.3 mm³) were performed on 45 MS patients. A model-based method was used for myelin/axonal/extracellular water fraction mapping from the unsuppressed water signals.

Results: Our method captured concurrent myelin/axonal/extracellular water fraction and neurometabolic alterations between lesion and normal tissues, as well as across patient groups.

Impact: Simultaneous high-resolution whole-brain metabolic imaging and myelin/axonal water fraction mapping may provide useful biomarkers to characterize MS pathophysiology.

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