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Abstract #3742

Gray matter metabolic changes and atrophy in multiple sclerosis correspond to neurotransmitter maps

Yan Xie1, Shaolong Wu1, Hongquan Zhu1, Xiaoxiao Zhang2, and Wenzhen Zhu1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Clinical Technical Solutions, Philips Healthcare, Beijing, China, Beijing, China

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, sodium magnetic resonance imaging

Motivation: A clearer understanding of metabolic abnormalities and irreversible damage in brain would provide valuable insights into the pathophysiology of multiple sclerosis (MS).

Goal(s): To explore gray matter (GM) sodium accumulation and atrophy in MS by 23Na-MRI and 1H-MRI.

Approach: The differences in total sodium concentration (TSC) and volume were compared between MS and healthy controls (HC). Spatial correlations between the differences of regional TSC or volume and neurotransmitter maps were investigated using JuSpace toolbox.

Results: Sodium accumulation occurs primarily in cortical regions of MS, whereas atrophy occurs mostly in subcortical regions. Regional GM damage with specific neurotransmitter systems is associated with clinical manifestations.

Impact: We illustrated the important role of altered sodium concentration in the pathophysiological mechanisms of MS and provided new insights into the relationship between GM metabolic alteration and irreversible neuronal loss and neurotransmission function.

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