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Abstract #3745

PRL-enhanced SWI: Paramagnetic Rim Lesion-enhanced Susceptibility Weighted Imaging for Multiple Sclerosis

Taechang Kim1, Eun Seon Jeong2, Yangsean Choi2, and Jongho Lee1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Korea, Republic of

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, Chi-separation, Quantitative Susceptibility Mapping

Motivation: The paramagnetic rim lesion (PRL) has recently been suggested as an important biomarker for the diagnosis and treatment monitoring of multiple sclerosis (MS).

Goal(s): Our goal is to create a new paramagnetic-susceptibility enhancing imaging which accentuates MS lesions, particularly PRL and central vein sign (CVS).

Approach: PRL-enhanced SWI is proposed, utilizing a high-pass filtered paramagnetic susceptibility map from χ-separation and an improved mask to differentiate a rim and inside of it.

Results: PRL-enhanced SWI provides a conventional SWI-like contrast that is familiar to radiologists and visualizes MS-specific lesions including PRL and CVS with an enhanced contrast-to-noise ratio.

Impact: PRL-enhanced SWI shows a potential as a valuable clinical tool for distinguishing MS lesions from non MS-specific lesions and may improve diagnostic accuracy.

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