Keywords: Multiple Sclerosis, Multiple Sclerosis, Chi-separation, Quantitative Susceptibility Mapping
Motivation: The paramagnetic rim lesion (PRL) has recently been suggested as an important biomarker for the diagnosis and treatment monitoring of multiple sclerosis (MS).
Goal(s): Our goal is to create a new paramagnetic-susceptibility enhancing imaging which accentuates MS lesions, particularly PRL and central vein sign (CVS).
Approach: PRL-enhanced SWI is proposed, utilizing a high-pass filtered paramagnetic susceptibility map from χ-separation and an improved mask to differentiate a rim and inside of it.
Results: PRL-enhanced SWI provides a conventional SWI-like contrast that is familiar to radiologists and visualizes MS-specific lesions including PRL and CVS with an enhanced contrast-to-noise ratio.
Impact: PRL-enhanced SWI shows a potential as a valuable clinical tool for distinguishing MS lesions from non MS-specific lesions and may improve diagnostic accuracy.
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