Keywords: Multiple Sclerosis, Multiple Sclerosis
Motivation: The impact of paramagnetic rim lesions (PRL) and black hole lesions (BH) on physiopathology and clinical outcomes in relapsing-remitting multiple sclerosis (RRMS) patients is not well understood.
Goal(s): To assess myelin and axonal content in PRL and BH coexisting lesions and their clinical significance in RRMS patients.
Approach: Neurite density index (NDI) and Susceptibility Source Separation (SSS) maps were used to compare myelin and axonal content across PRL+BH+, PRL+BH-, PRL-BH+, and PRL-BH- lesions.
Results: PRL+BH+ lesions showed the lowest myelin and axonal content and were most strongly associated with cognitive and physical disability, highlighting their greater clinical relevance.
Impact: PRL+BH+ is a more destructive subset of PRL associated with disability in RRMS. Preventing PRL+BH- from converting to PRL+BH+ may help slow disability progression. This imaging feature also provides a novel outcome variable for clinical cohort studies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords