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Abstract #3746

Characterizing Paramagnetic Rim Lesions in Relapsing-Remitting Multiple Sclerosis: A Study on Myelin Content and Axonal Density

Zhuowei Shi1, Qiyuan Zhu1, Zichun Yan1, Lisha Nie2, and Yongmei Li1
1The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, 2GE HealthCare MR Research, Beijing, China, Chongqing, China

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: The impact of paramagnetic rim lesions (PRL) and black hole lesions (BH) on physiopathology and clinical outcomes in relapsing-remitting multiple sclerosis (RRMS) patients is not well understood.

Goal(s): To assess myelin and axonal content in PRL and BH coexisting lesions and their clinical significance in RRMS patients.

Approach: Neurite density index (NDI) and Susceptibility Source Separation (SSS) maps were used to compare myelin and axonal content across PRL+BH+, PRL+BH-, PRL-BH+, and PRL-BH- lesions.

Results: PRL+BH+ lesions showed the lowest myelin and axonal content and were most strongly associated with cognitive and physical disability, highlighting their greater clinical relevance.

Impact: PRL+BH+ is a more destructive subset of PRL associated with disability in RRMS. Preventing PRL+BH- from converting to PRL+BH+ may help slow disability progression. This imaging feature also provides a novel outcome variable for clinical cohort studies.

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