Abstract #3747

A neuro-metabolic MRI evaluation of the impact that dietary improvement has on MS: A pilot study

Oun Al-iedani^1,2, Olivia Wills³, Vicki E Maltby^2,4,5, Rodney Lea², Saadallah Ramadan^2,5, Yasmine Probst³, and Jeannette Lechner-Scott^2,4,5

¹School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia, ²Immune Health Research Program, Hunter Medical Research Institute, New Lambton Heights, Australia, ³School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, Australia, ⁴Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia, ⁵School of Medicine and Public Health, University of Newcastle, Callaghan, Australia

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, MS Diet, Magnetic resonance spectroscopy imaging (MRSI)

Motivation: People living with Multiple Sclerosis (plwMS) often experience poor dietary habits, which negatively impacts disease progression. A non-pharmacological approach that improves diet quality may help slow MS progression. The neuro-metabolic implications of diet quality in plwMS remain unexplored.

Goal(s): Investigate the impact of 3-month dietary intervention on neuro-metabolites in plwMS using fast MR spectroscopy(MRS).

Approach: A pilot study was conducted on eight plwMS, involving a three-month dietary intervention with regular coaching, and MRS scans pre-and post-intervention to analyse neuro-metabolic changes.

Results: The short-term dietary intervention led to significant improvements in dietary quality and neuro-metabolites, indicative of benefits of diet improvement on MS progression.

Impact: This pilot study demonstrates the potential of dietary interventions for influencing the neuro-metabolic composition of plwMS, warranting a larger-scale trial. This research could lead to novel, non-pharmacological approaches for managing MS, potentially improving patient outcomes and quality of life.

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