Meeting Banner
Abstract #3750

Impaired Glymphatic and Lymphatic Contrast Clearance in Multiple Sclerosis: Quantitative Analysis of dFLAIR Imaging at 7T MRI

Li Jiang1,2, Jiachen Zhuo1,2, Prashant Raghavan Raghavan1, Lakir D. Patel3, Seongjin Choi3, and Daniel M. Harrison3
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States, 2Center for Advanced Imaging Research, University of Maryland Baltimore, Baltimore, MD, United States, 3Department of Neurology, University of Maryland Baltimore, Baltimore, MD, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, 3D-FLAIR, lymphatic and glymphatic systems, waste clearance

Motivation: Multiple sclerosis (MS) is a progressive neuroinflammatory disease marked by impaired waste clearance in the brain. Researches suggested that dysfunction in the brain lymphatic and glymphatic systems may contribute to MS pathophysiology.

Goal(s): To investigate contrast dynamics within MS-affected glymphatic regions, assessing the role of clearance pathways in MS using contrast-enhanced MRI.

Approach: We analyzed high-resolution difference FLAIR (dFLAIR) imaging data from 7T MRI, capturing contrast agent distribution at early and late post-contrast time points.

Results: Results revealed distinct contrast dynamics across glymphatic-related regions in MS, characterized by reduced early contrast uptake and delayed clearance at the late post-contrast time point.

Impact: This study highlights altered glymphatic function as a potential biomarker for MS disease progression. Findings underscore the utility of 7T dFLAIR imaging in assessing glymphatic clearance, opening pathways for improved diagnostic and therapeutic strategies targeting waste clearance in MS patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords