Keywords: Multiple Sclerosis, Multiple Sclerosis, Myelin Water Imaging
Motivation: Multiple sclerosis lesions contribute to progression of disability. Spinal cord lesions are of particular importance due to the small cross-sectional area of the cord and presence of important tracts.
Goal(s): Determine if myelin damage in lesions could be used as a potential prognostic biomarker of disease progression.
Approach: Use myelin water imaging to determine myelin content in lesional, perilesional and white matter tissue, and correlate with change in clinical tests over 5 years.
Results: We determine a gradient of myelin damage beyond what is visible on conventional imaging. We strongly correlated myelin damage in the lesion and surrounding tissue to accrual of disability.
Impact: Spinal cord myelin imaging of lesional and perilesional tissue may be useful as a prognostic biomarker for monitoring patients with progressive multiple sclerosis (MS) especially in clinical trials for progressive MS, for which therapies are lacking.
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