Meeting Banner
Abstract #3751

Perilesional myelin damage around multiple sclerosis spinal cord lesions predicts change in disability over 5 years in progressive MS.

Poljanka Johnson1, Elys Jamieson2, Irene M Vavasour3, Cornelia Laule4, David K.B. Li3, Anthony Traboulsee1, and Shannon K.B. Kolind5
1Medicine (Neurology), University of British Columbia, VANCOUVER, BC, Canada, 2Physics and Astronomy, University of British Columbia, VANCOUVER, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Physics and Astronomy, Radiology, Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 5Physics and Astronomy, Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, Myelin Water Imaging

Motivation: Multiple sclerosis lesions contribute to progression of disability. Spinal cord lesions are of particular importance due to the small cross-sectional area of the cord and presence of important tracts.

Goal(s): Determine if myelin damage in lesions could be used as a potential prognostic biomarker of disease progression.

Approach: Use myelin water imaging to determine myelin content in lesional, perilesional and white matter tissue, and correlate with change in clinical tests over 5 years.

Results: We determine a gradient of myelin damage beyond what is visible on conventional imaging. We strongly correlated myelin damage in the lesion and surrounding tissue to accrual of disability.

Impact: Spinal cord myelin imaging of lesional and perilesional tissue may be useful as a prognostic biomarker for monitoring patients with progressive multiple sclerosis (MS) especially in clinical trials for progressive MS, for which therapies are lacking.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords