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Abstract #3752

Probing white matter microstructure in multiple sclerosis patients using standard model diffusion MRI

Chaoyang Jin1, Ahmad A Toubasi2, Caroline Gheen2, Taegan Vinersky2, Xiaoyu Jiang1, Francesca Bagnato2,3, and Junzhong Xu1
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Neurology, VA HealthCare System, Nashville, TN, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: The Standard Model Imaging (SMI) technique, based on diffusion magnetic resonance imaging (MRI), introduces a novel approach for detecting microstructural features of white matter (WM).

Goal(s): This study aims to implement SMI to characterize WM injury in people with MS (PwMS) brains and investigate its clinical feasibility

Approach: Four different types of brain tissues in PwMS were manually outlined, representing different levels of tissue injury. The SMI-derived microstructural metrics were compared among different tissue types.

Results: SMI-derived axonal fraction f and extra-axonal perpendicular $$$D_e^\perp$$$ not only distinguish MS lesions from normal appearing WM (NAWM) but also differentiate MS lesions with different severity.

Impact: SMI-derived metrics are sensitive to pathological changes in MS lesions and show promise for clinical applications in MS.

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