Keywords: Multiple Sclerosis, Multiple Sclerosis, glymphatic system, along perivascular space index, choroid plexus volume, cognitive impairment, mediation analysis
Motivation: Identifying more MRI biomarkers is needed to better understand the pathological processes responsible for relapsing-remitting multiple sclerosis (RRMS)-related cognitive impairment (Co-I).
Goal(s): To investigate the association between choroid plexus volume (CPV) and cognition in RRMS and analyze whether it was mediated by the glymphatic function.
Approach: 60 MS patients and 44 healthy controls were enrolled. DTI-ALPS indexes were calculated. Correlations between DTI-ALPS and CPV and cognitive performance were analyzed.
Results: RRMS patients with Co-I showed lower ALPS-index and higher CP volume. ALPS-index mediated the effect of enlarged CP on cognitive function.
Impact: The impact of enlarged CP on cognitive function is mediated by glymphatic alterations, indicating a pathological mechanism for MS-related cognitive impairment.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords