Abstract #3757

Ultra-High Contrast (UHC) MRI of the Brain and Spinal Cord in Multiple Sclerosis Using Divided Subtracted Inversion Recovery Sequences

Paul Condron^1,2, Daniel Cornfeld^1,2, Mark Bydder¹, Catherine Shi¹, Taylor Emsden¹, Karen Whitehead³, Gil Newburn¹, Miriam Scadeng^1,2, Samantha J Holdsworth^1,2, and Graeme Bydder^1,4

¹Mātai Medical Research Institute, Gisborne, New Zealand, ²Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland,, Auckland, New Zealand, ³Multiple Sclerosis Society, Gisborne, New Zealand, ⁴University of California, San Diego, San Diego, CA, United States

Synopsis

Keywords: Multiple Sclerosis, Neuroinflammation, White Matter

Motivation: Ultra-high contrast (UHC) divided subtracted inversion recovery (dSIR) sequences were used in multiple sclerosis patients during relapse and remission in a proof of principle study.

Goal(s): To compare dSIR imaging with conventional imaging in the brain and spinal cord.

Approach: Directly acquired and synthetic 2D and 3D narrow and wide middle Domain dSIR images were compared with positionally matched conventional images.

Results: Well defined focal lesions were seen with dSIR sequences where no change was seen with conventional sequences. Widespread abnormalities affecting almost all of the white matter were seen during relapse with no abnormality on conventional sequences.

Impact: Ultra-high contrast (UHC) divided subtracted inversion recovery (dSIR) sequences were used in patients with multiple sclerosis during relapse and in remission. Well defined focal lesions and very widespread abnormalities in white matter were shown when conventional imaging appeared normal.

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