Abstract #3760

Patterns of Lesion Volume Evolution in Multiple Sclerosis: Associations with Microstructural Change and Neuroaxonal Damage

Martina Greselin^1,2,3, Po-Jui Lu^1,2,3, Alessandro Cagol^1,2,3,4, Esther Ruberte^1,2,3,5, Mario Ocampo Pineda^1,2,3, Sabine Schaedelin^1,2,3, Lester Melie-Garcia^1,2,3, Xinjie Chen^1,2,3, Riccardo Galbusera^1,2,3, Matthias Weigel^1,2,3, Jens Kuhle^1,2, Ludwig Kappos^1,2, Habib Ganjgahi^6,7, and Cristina Granziera^1,2,3

¹Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ²Department of Neurology, University Hospital Basel, Basel, Switzerland, ³Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, ⁴Department of Health Sciences, University of Genova, Genova, Italy, ⁵Medical Image Analysis Center (MIAC) and qbig, Department of Biomedical Engineering, University Basel, Basel, Switzerland, ⁶Statistics Department, University of Oxford, Oxford, United Kingdom, ⁷Big Data Institute, University of Oxford, Oxford, United Kingdom

Synopsis

Keywords: Multiple Sclerosis, Neuroinflammation, Lesion evolution

Motivation: Measuring lesion volume evolution in Multiple Sclerosis patients is fundamental to assessing disease progression and clinical worsening.

Goal(s): Classify white matter lesions based on their volume evolution and investigate whether they are associated with microstructural changes and neuroaxonal damage.

Approach: Lesion volume evolution was assessed using the Jacobian methods applied to FLAIR MRI images; microstructural changes were quantified using T1 relaxometry from MP2RAGE, and neuroaxonal damage was assessed via serum neurofilament light chain levels.

Results: Our findings revealed distinct lesion clusters based on volume change trajectories, with significant associations between these clusters and MRI and serum markers of tissue damage.

Impact: These findings can reflect the importance of chronic neurodegenerative processes within MS lesions and provide a foundation for further investigation into the mechanisms of disease progression and clinical worsening in pwMS.

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