Abstract #3761

Potential application of magnetization transfer-indirect spin labeling MRI for imaging multiple sclerosis at 3T

Ziyan Wang¹, Pei Cai¹, Jiawen Wang¹, Huabin Zhang^1,2, Shihao Zeng¹, and Jianpan Huang^1,3

¹Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, ²Medical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China, ³Tam Wing Fan Neuroimaging Research Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Synopsis

Keywords: Multiple Sclerosis, Neurofluids

Motivation: MISL MRI in imaging the water exchange between CSF and brain tissue of human brain remains unexplored.

Goal(s): This study aims to optimize the MISL MRI at clinical 3T and utilize it for imaging water exchange in multiple sclerosis (MS).

Approach: Echo time was first optimized for MISL MRI, which was then applied for imaging 19 healthy controls (HCs) and 12 MS patients on a clinical 3T MRI scanner.

Results: A TE of ≥140 ms is applicable for MISL MRI of human brain at 3T. MISL MRI detected a decreasing trend in water exchange tissue in MS patients.

Impact: This study optimized the echo time for MISL MRI of human brain at clinical 3T. MISL MRI detected a decreasing trend in water exchange between CSF and brain tissue in MS patients, suggesting its potential for imaging neurological diseases.

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