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Abstract #3773

R1 dispersion mapping of cerebral small vessel disease using Field-Cycling Imaging

Nicholas Senn1, Vasiliki Mallikourti1, P. James Ross1, Reina Ayde2, Lionel M. Broche1, Gordon D. Waiter1, and Mary Joan MacLeod3
1Aberdeen Biomedical Imaging Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, United Kingdom, 2AMT Center, Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, United Kingdom, 3Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, United Kingdom

Synopsis

Keywords: Aging, Novel Contrast Mechanisms, Field-Cycling MRI, R1 dispersion, small vessel disease

Motivation: Field-Cycling Imaging accesses new biomarkers of pathology by mapping the dispersion of spin-lattice R1 with magnetic field strength below 0.2 T.

Goal(s): To examine the efficacy of Field-Cycling Imaging to interrogate field-dependence of R1 in brain changes arising from cerebral small vessel disease.

Approach: Twenty participants were recruited with moderate or severe small vessel disease and underwent 3T MRI and FCI scans, repeated 30 days apart.

Results: Differences in R1 dispersion could repeatably be discerned between normal and abnormal appearing brain tissue regions using Field-Cycling Imaging.

Impact: This work is a first step towards investigating whether quantitative measurements of low-field R1 dispersion have utility for assessing progression of cerebral small vessel disease.

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Keywords