Abstract #3776
Cardiovascular risk factors are associated with brain ageing
Mathijs B.J. Dijsselhof1,2, Carole H. Sudre3,4, Sarah N. James3, Nishi Chaturvedi3,5, Alun D. Hughes3, Hans R. Jäger6, Magdalena Sokolska 7, David Atkinson8, Lorna Smith9, Lars T. Westlye10,11,12, James H. Cole8,13, Frederik Barkhof1,2,8,14, Jan Petr1,15, and Henk J.M.M. Mutsaerts1,2
1Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands, 3MRC Unit for Lifelong Health and Ageing, University College London, London, United Kingdom, 4Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 5Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London,, London, United Kingdom, 6Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 7Medical Physics and Biomedical Engineering, University College London Hospitals,, London, United Kingdom, 8Centre for Medical Imaging, University College London, London, United Kingdom, 9Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, United Kingdom, 10Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway, 11Psychology, University of Oslo, Oslo, Norway, 12KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway, 13Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom, 14Queen Square Institute of Neurology, University College London, London, United Kingdom, 15Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany
Synopsis
Keywords: Aging, Aging, Arterial Spin Labeling
Motivation: Accelerated structural and cerebrovascular brain ageing is associated with cognitive decline. However, it is unknown how cardiovascular risk factors (CRF), differing between ethnicities and associated with structural and vascular brain health, are related to accelerated brain ageing.
Goal(s): To assess the associations of CRF with structural and cerebrovascular brain ageing, in three ethnic groups.
Approach: Accelerated brain ageing was assessed by determining the difference in chronological and T1w, FLAIR, and Arterial Spin Labelling-derived brain age using machine learning.
Results: Cerebrovascular — but not structural — brain age was associated with several CRF. There were no ethnicity interactions.
Impact: Multi-modal brain age assessments may enable a better understanding of the effects of ageing-related pathology, such as CRF, on the brain. This allows future brain ageing studies to investigate structural and cerebrovascular components of cognitive decline and cerebral pathology.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
