Abstract #3778

Age-related variations in T1/T2 ratios and perfusion in the deep gray matter nuclei: An MRI study of healthy individuals

Miaoqi Zhang^1,2, Chao Wang^1,2,3, Zhe Sun^1,2, Chenyang Li^1,2, Jiangyang Zhang^1,2, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Aging, Aging

Motivation: It remains unclear about MRI signal intensity (i.e. T1/T2 ratio) and perfusion changes during aging, and the relationship between T1/T2 ratio and perfusion in deep gray matter nuclei (DGMN).

Goal(s): Systematically exploring the changes of T1/T2 ratio, CBF and ATT during aging and the intensity-perfusion relationship in DGMN.

Approach: T1 and T2-weighted and ASL imaging data from 657 healthy adults in the HCP-Aging dataset were used to analyze the changes of T1/T2 ratios, CBF and ATT during aging, and the intensity-perfusion relationship in DGMN.

Results: T1/T2 ratio and CBF decreased with age. ATT increased with age. Lower T1/T2 ratios correlated with increased CBF.

Impact: Using a large cohort dataset, our study revealed the changes of signal intensity and cerebral perfusion during aging, which may enhance the understanding of the underlying tissue and vascular changes during aging.

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