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Abstract #3784

Effect of Ayurvedic formulation on metabolic profile of posterior cingulate cortex in ageing population

Arman Deep Singh1, Mukesh Kumar1, Bhargavi P1, Swathi BH1, Subash Khushu1, and Ashwini Godbole1
1University of Trans-Disciplinary Health Sciences and Technology, Bengalore, India

Synopsis

Keywords: Other Interventional, Aging, MRS, PCC, Cognition, Choline

Motivation: The growing elderly population has led to a rise in cognitive impairments and neurodegenerative disorders. Development of therapeutic strategies to stop and revert these changes are essential.

Goal(s): To find age related changes in PCC and effect of Brahmi Ghrita on these changes in posterior cingulate cortex.

Approach: 54 healthy Indians underwent brain scanning for MR spectroscopy and 8 participants have completed the intervention.

Results: Total choline, myo-Inositol and total creatine found to significantly increased in elderly as compared to young and middle-aged participants. Brahmi Ghrita intervention have reduced the concentration of total choline in PCC.

Impact: The study highlights age-related metabolic changes in the posterior cingulate cortex, revealing increased choline, myo-inositol, and creatine levels in the elderly. Importantly, Brahmi Ghrita shows potential in reversing these changes, suggesting a therapeutic avenue for cognitive health.

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