Keywords: Contrast Agents, Tumors
Motivation: Ultra-small manganese ferrite nanoparticles (UMFNPs) have achieved promising outcomes in tumor detection and diagnosis as T1 contrast agents. Given the unique molecular composition, we posit that UMFNPs also hold considerable promise for T2WI and SWI.
Goal(s): This study aims to systematically investigate the application potential of unfunctionalized 3 nm UMFNPs in tumor multi-modal MR imaging.
Approach: Using a breast cancer subcutaneous tumor model, we employed T1WI, T2WI and SWI to evaluate the effectiveness of 3 nm UMFNPs in tumor imaging.
Results: We successfully detected signal alterations across all three imaging modalities in tumor regions following intratumoral or intravenous injection of 3 nm UMFNPs.
Impact: Multi-modal tumor imaging with a single administration provides more comprehensive information and will enhance the accuracy and reliability of tumor diagnosis. This research highlights the potential of 3 nm UMFNPs as a versatile and powerful tool for MRI-based cancer diagnostics.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords