Abstract #3864

Magnetic Resonance Imaging (MRI) to visualise tablet disintegration and dissolution in the fed stomach

Tejal Rasiklal Akbar¹, Luca Marciani¹, Pavel Gershkovich², Snow Stolnik-Trenkic³, James Butler⁴, Konstantinos Stamatopoulos⁴, and Penny Gowland⁵

¹Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, ²School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom, ³School of Pharmacy, University of Nottingham, Nottingham, United Kingdom, ⁴GSK, Ware, United Kingdom, ⁵University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom

Synopsis

Keywords: Contrast Agents, Contrast Agents, digestive, drug development, drugs, visualisation

Motivation: Tablets are the most common formulations for oral drug delivery, however the processes of tablet disintegration and dissolution in the human stomach, in vivo, are difficult to study, particularly in the fed stomach.

Goal(s): Our goal is to use MRI to visualise tablet disintegration and dissolution in the fed stomach.

Approach: Various tests were performed to image tablets in the fed stomach. These were manufactured with added manganese gluconate to improve MRI visibility.

Results: The use of manganese added to tablets enhanced their MRI visibility in the fed stomach. Disintegration and dissolution of the tablets was observed.

Impact: MRI can provide insight into tablet disintegration and dissolution in the fed stomach. This has the potential to benefit drug development, by improving correlation between in vitro measurements and in vivo and informing in-silico modelling.

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